Beta
ManageSearchChatDiscover
311248

GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUE

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical analytical chemistry and instrumental analysis

Abstract

Development and validation of three simple, eco-friendly, accurate and precise chemometric models have been presented for the spectrophotometric determination of ciprofloxacin (CIP), indomethacin (IND), and metronidazole (MET) residues in production wastewater samples. These methods are classical least square (CLS), principal component regression (PCR) and partial least square (PLS-1). A 3-factor 5-level experimental design was built leading to 25 mixtures containing different ratios of CIP, MET, and IND. Thirteen mixtures were used as a training set, and the other twelve were used as a validation set. Using of multi-wavelengths instead of the single wavelength spectrophotometry has greatly improved the precision and predictive abilities of these multivariate calibrations. The proposed methods have been found to be accurate, precise and can be used for determination of the drugs in pure form and industrial wastewater samples without preliminary separation steps. The methods described were used to accurately assess the drug residues in laboratory-prepared mixtures and actual industrial wastewater samples to confirm that it is free from these drug residues so it can be recycled and used for irrigation and other purposes.

DOI

10.21608/ajps.2023.311248

Keywords

ciprofloxacin, Indomethacin, Metronidazole, chemometrics, Wastewater

Authors

First Name

Islam

Last Name

Selim

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry, School of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt.

Email

islam.selim@buc.edu.eg

City

-

Orcid

-

First Name

Osama

Last Name

Abdel Sattar

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Hamed

Last Name

Abuseada

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Emara

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt., Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt. 3 Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Menoufia University, Shebin Elkom, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Serag

MiddleName

-

Affiliation

Department of Pharmaceutical Analytical Chemistry Dept., Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt.

Email

ahmedserag777@yahoo.com

City

-

Orcid

-

Volume

67

Article Issue

1

Related Issue

42767

Issue Date

2023-03-01

Receive Date

2023-08-05

Publish Date

2023-03-01

Page Start

84

Page End

99

Print ISSN

1110-1644

Online ISSN

2535-1958

Article File

AJPS_Volume 67_Issue 1_Pages 84-99.pdf

PDF . 749.9kB

Link

https://ajps.journals.ekb.eg/article_311248.html

Detail API

https://ajps.journals.ekb.eg/service?article_code=311248

Order

311,248

Type

Original Article

Type Code

518

Publication Type

Journal

Publication Title

Al-Azhar Journal of Pharmaceutical Sciences

Publication Link

https://ajps.journals.ekb.eg/

MainTitle

GREEN CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF CIPROFLOXACIN, METRONIDAZOLE, AND INDOMETHACIN RESIDUES IN PHARMACEUTICAL INDUSTERIAL WASTEWATER EFFLUENTS

Details

Type

Article

Created At

23 Dec 2024