This study aimed to evaluate the effect of fungicides ,essential oils , biocides and fertilizers on Plasmopara viticola the causal organism of downy mildew in three varieties of grapes at three governorates( Aldaqahlia , Albehira and Almonofia) on three seasons ,the first season evaluated the effect of fungicides in reducing the disease severity ,Ridomil gold plus ,Equation pro and Antracol gave high effect in decreasing the disease ,the second season tested essential oils , biocides and fertilizers separately on the pathogen; cinnamon and rosemary were the best in controlling the disease however Plantaguard , Rhizo N and Chitosan decreasing the disease, the third season evaluated integrated control program which contained all tested compounds combined but in certain order according to dormancy stage , flowering and fruiting to reduce number of sprays fungicides and using eco-environmental compounds on vine leaves and fruits in field conditions, the program gave very high effect in reducing the disease severity of downy mildew in grapes for all governorates in three varieties of grapes ( flame , crimson and thompson)