Six treatments of some insecticides with different modes of action were tested against the mango shield scale (MSS), Milviscutulus mangiferae (Green) different stages on mango host plant trees. This study aimed to differentiate among the used insecticides (Spirotetramat (Movento), 10% SC; sulfoxaflor (Isoclast), 50% WG and mineral oil (KZ Oil^®) 95% EC) regarding their reduction of each M. mangiferae stage as well as its total population. Nimbecidine 0.03% (Azadirachtin) bio-insecticide was mixed with the Spirotetramat (Movento^®) and sulfoxaflor (Isoclast^®) at half application rate of each. All the treated insect stage populations were differently affected in a function of the treated stage, the tested compound, and the time after treatment (exposure time) with continuous high activity even after 8 weeks of treatment. The differences in the effect are due to their different modes of action. Both the 1^st and the 2^nd nymph instars were less affected than the other treated stages (adult and crawler) with all the tested insecticides. The obtained reduction % appeared in a non-systematic arrangement with the time of exposure. The mineral oil (Kz oil^®) appeared the most effective, followed by the mixture of Nimbecidine® 0.03% azadirachtin at 250 ml/100 L and Sulfoxaflor (Isoclast^®) 50% WG at 62.5 gm/ 200 L; Sulfoxaflor (Isoclast^®) 50% WG at 125 gm/ 200 L; the mixture of Nimbecidine^® 0.03% at 250 ml/ 100 L and Spirotetramat (Movento^®) 10% SC at 20 ml/ 200 L; Spirotetramat (Movento^®) 10% SC at 40 ml/ 200 L and Nimbecidine^® 0.03% (azadirachtin) at 500 ml/ 100 L. Mixing the bio-insecticide Nimbecidine^® 0.03% azadirachtin with the synthetic insecticides at half the application rate of each enhanced the reduction by decreasing their harmful effects on the environment and non-target biota