Aim: the aim of this study to assess and compare changes in gained bone height following sinus augmentation by two different biomaterials, Hyaluronic acid versus simvastatin as osteoconductive materials.

Material and Methods: a randomly allocated twenty patients with edentulous posterior maxilla into 2 groups. All sinuses were augmented by open lateral window using one of the combinations of simvastatin and β-TCP as group A or hyaluronic acid mixed with xenograft as group B. The amount of newly formed bone was evaluated by radiographic analysis. This assessment was occurred at period intervals one week and six months postoperatively. The histological evaluation was done to the bone collected by trans-crestal bone biopsies taken after six months during the second-stage surgery for implant placement. All collected data were tabulated as mean and standard deviation (SD) values. The comparisons between the groups was done by Fisher's Exact test. The significance level was set at P ≤ 0.05.

Results: radiographic and descriptive histological analysis showed superior results in favor of sinus augmented with TCP- Simvastatin complex in terms of amount of bone gain and histological bone maturation.

Conclusion: it was clinically valuable to use the hyaluronic acid and Simvastatin as safe bone grafting materials in cases of antral augmentation with the superiority in bone gain and maturation in favor of TCP- Simvastatin complex.