Odontogenic Keratocyst (OKC) is a benign cystic lesion characterized with aggressive behavior and relatively high recurrence
rate. Most of the current suggested therapeutic surgical approaches are jeopardizing vital structures and integrity of the mandible
ending with unjustified resections. We aim to evaluate the validity of decompression as a curative treatment for OKC
Patients and Methods: Prospective case series studies of 10 patients were diagnosed with OKC through clinical, radiographical
and pathological examination. All patients were treated with decompression. Histopathological features and volumetric changes
were evaluated during follow up periods at 3, 6 and 9 months postoperatively.
Results: All OKC lesions showed positive response to decompression. Age ranged from 8 to 45 with mean age of 25.9 years.
Lesions' size ranged from 47478.6 mm3 to 4615.52 mm3 with mean size of 20949.5 mm3. Reduction rate percentage in a
period of 9 months follow up was 80.36% (P-value=0.002)
Conclusion: Decompression is a noninvasive preliminary curative approach for treating OKC.