Abstract The research aimed to measure the impact of integration between the application of the flexible Six Sigma methodology and the value stream costs method in order to achieve business sustainability, and in order to achieve the objectives of the research, the applied approach was used depending on the financial and non-financial statements of the company under study to demonstrate the impact of integration between the flexible Six Sigma methodology and the value stream costs method in order to achieve business sustainability and also the descriptive analytical approach was used depending on the answers of the research sample and on the data that was made through the questionnaire, which is the tool used Which was distributed to a sample of some workers and administrators, and the hypotheses were tested statistically using the statistical program SPSS. The study concluded by comparing the traditional production performance indicators currently applied with modern and advanced methodologies for quality, costs, waste management and sustainability dimensions of production organizations, and that the application of these methodologies contributes strongly to reducing quality costs and the flow of materials and processes in a smooth manner that helps the production company to raise the level of quality.