The aim of the research is to shed light on the obstacles facing small and medium enterprises in Cairo Governorate from the point of view of the owners. Cairo Governorate, the data was collected, organized and analyzed statistically. The research reached a set of results, the most important of which were: small and medium enterprises in Cairo governorate suffer from a lack of liquidity level, which limits the development and progress of these projects, and the reason is insufficient government support, there is no database in the real sense, or even if it exists, its performance is poor. The lack of technical expertise and competencies in small and medium enterprises in Cairo Governorate, and the weakness of training programs, medium and small enterprises in Egypt suffer from many problems, obstacles and challenges that affect the efficiency of the productive unit and its ability to compete externally. The study recommended increasing awareness of the importance of these projects, clarifying their role in economic development, encouraging banks to finance these projects, and provide loans and the necessary support.