Background: Burn out is a prevalent condition that affects healthcare personnel in different specialties as they are exposed to high levels of stress at work. It includes emotional exhaustion, depersonalization, and low personal accomplishment. Burnout among Physicians has received much attention because of its negative impact on medical personnel, health and performance. Objective: To measure the prevalence of burn out among physicians enrolled in the Egyptian fellowship training program and identify risk factors for burnout among them. Subjects and methods: This study is a cross sectional study. Four hundred physicians enrolled in the Egyptian fellowship program were included in this study. A self-administered written questionnaire consisted of three sections was used for data collection: section (1) socio-demographic data, place and load of work, (2) habits, physical activities, smoking and watching TV. Section (3) Maslach Burnout Inventory (MBI). Results: Male physicians represented 77% of our sample with mean age ± SD (34.1 ± 4.4); the prevalence of burnout among participants was 37.5%. Regarding MBI subscales scores, there were significant high level of depersonalization (78.8%) among participants, then emotional exhaustion level (64.5%) and low Personal accomplishment score was recorded in (59.3 %). It was found that working hours extended to more than 40 hours /week, surgical specialties and number of night shifts more than 3 per week were independent risk factors for burnout among the studied group. Also, non-smokers Egyptians physicians and those with less physical activities showed high levels of depersonalization and low personal accomplishment.   Conclusion: the high prevalence of burn out among physicians attending Egyptian fellowship training program requires concentrated efforts at the occupational, socio-psychological, individual, and organizational levels to address executive plans and procedures to combat burn out negative impacts on physician's mental health wellbeing, patients and health care services provision. Keywords: burnout, job-related stress, occupational, physicians, healthcare workers.