Climate change has become a threat to livelihoods, public health, infrastructure, water security, food security and energy security. Egypt is one of the regions most affected by climate change despite its relatively small contribution to global greenhouse gas emissions. Globally, the inter-linkages between water, energy, and food sectors have been increasingly investigated over the last few years under what has come to be referred to as the "Water-Energy-Food (WEF) nexus". The strong interlinkages between the sectors can affect the extent to which three crucial policy objectives can be achieved, i.e., water, energy, and food security. The interlinkages mean that pursuing security in one sector depends on the developments in other sectors. Therefore, it is becoming imperative that policy formulation should be coordinated among the three sectors as well as with respect to mitigation of- and adaptation to climate change. Conventional policy- and decision-making in ‘silos' therefore needs to give way to an approach that reduces trade-offs and builds synergies across sectors. Adopting a interdependence approach for these three sectors would give the opportunity to innovate and educate to reduce security risks, maximize opportunities, increase possibilities and enhance resource efficiency. the research paper aims at enhancing the interconnection approach between water , energy, and food security and how it contributes to mitigate the negative effects of climate change.