The current study aimed at investigating the effect of a program based on the 4MAT (McCarthy) Model on developing creative reading and self-efficacy of English Majors at Women's College, Ain Shams University. The one-group research design was adopted in the study and two measurement tools were used; a pre-post creative reading test and a self-efficacy questionnaire. A program based on the 4MAT Model was designed and applied to a sample of 33 fourth year English Majors in the educational section at Women's College, Ain Shams University in the first semester of the academic year 2021-2022. The intended creative reading sub components related to fluency, flexibility, originality and elaboration were introduced according to the stages of the 4MAT Model (motivation/reflective observation, concept making/information, active experimentation and concrete experiences/creative applications). The statistical analysis of the data obtained from the pre and post administration of the tools of the study revealed that the suggested program was effective in developing English Majors' creative reading and self-efficacy.