Two hundred and fifty, unsexed seven-days-old Japanese quails were randomly distributed into 5 experimental groups (50/group), with five replicates each to test the hypothesis that dietary supplementation of fungi will improve the performance of Japanese Quail fed basal diet supplemented with 10%  DPW. The quails of the five groups were fed according to the following order: the 1^st group served as control and received a basal diet free of date palm waste (DPW). Quails in the 2^nd group were fed a diet containing 10% untreated DPW. Quails in the 3^rd, 4^th and 5^th groups were fed a diet containing 10% DPW treated with fungi (Aspergillus niger, Trichoderma and Trichoderma plus Aspergillus niger; respectively). Results showed that quail chicks fed diet included DPW treated by Trichoderma plus A. niger fungus had significantly the best recorded values of BW, BWG of all treatments at the end of growing period (42 days of age). On the contrary, the lowest recorded values of BW and BWG were recorded in group received DPW without Fungi supplementation, followed by group received DPW treated with fungi A. niger during the same period (P<.05). Furthermore, birds received (DPW +A+T) showed numerically but not significant FCR better than the control group without any supplementation.  Also, Quails fed diet included DPW at 10% showed lowered values of nutrient digestibility of DM, CP, EE and CF%, however, treatment with fungi retained the value of nutrient digestibility to the values of the control group fed basal diet without DPW. Quails fed basal diet included DPW treated by Trichoderma plus A. niger fungus recorded significantly the highest values of plasma total protein, globulin and glucose.  Also, JQ fed basal diet included DPW not treated or treated by Trichoderma plus A. niger had better economic efficiency and production index than the control during 7- 42 day of age. These results suggest that DPW treated with Trichoderma plus A. niger could be a potential feed ingredient for quail production due to its improvement in productive performance, digestibility, economic efficiency and production index. Further research is needed to investigate the long-term effects of feeding DPW to quails and other bird species.