The present work was deliberate to study effect of prebiotic, probiotic or combination of prebiotic and probiotic as synbiotic on productive measurements as growth and slaughter yield, digestibility of nutrients, blood indicates and some  intestinal bacterial counts of broiler chicks. A total of 120- Arbor Acres- at one day of age chicks were classified into four treatments (30 birds each). Broilers in the control clutch (T1) were fed starter and grower diet without supplementations. The second group (T2) was fed the same control added with 5.00 g (MOS) mannanoligosaccharides (as prepiotic). The third group (T3) was fed the same control diet plus 1.00 g Inviva-pro (as probiotic). Whereas, the fourth one (T4) was fed basal diet supplemented with  mixture of 5.00g mannanoligosaccharides plus 1.00 g Inviva- pro (as synbiotic) during starter and grower diet (from 1 to 20 and from 21 to 35 days old). The obtained data showed that the mean values of live body weight and body gain were highest (P < 0.05) for probiotic group (T3), feed effeciency was greatest (P < 0.05) in synbiotic group (T4) and feed intake had no significant changes among all treatments. The total count of bacteria in small and large intestine was significantly higher in treatment (T2) followed by (T3) as compared to the other treatments. Dressing yield percentage and liver weight significantly increased for broilers in T3 (probiotic) and T4 (synbiotic), respectively. There were no variances (P < 0.05) in digestibility of all nutrients for broilers in all treatments. Number of Lactobacilli in both small and large intestine was higher in all treatments than in the control (T1). In addition, The highest number of coliform was recorded in T4 (synbiotic) in small intestine with no significant differences in large intestine.. The highest values of amylase, lipase and trypsin were determined to T3 broilers. While, the highest value of chymotrypsin activity was recorded to T4 broilers. The highest (p˂0.01) total protein, globulin, triglycerides and basophils were recorded to synbiotic broilers group < strong>. In addition, probiotic group (T3) recorded the greatest values of glucose and neutrophils. Highest economic efficiency and relative economic efficiency were calculated to probiotic group.