This work conducted to appreciate the effect of dietary grape seeds powder (GS, as natural antioxidants) and butylated hydroxyl toluene (BHT, as syntheticantioxidants) addition on productive, physiological and antioxidants status as well as economic efficiency of broiler chicks during fattening period. A total of 540 unsexed Hubbard broiler chicks, 1-day old were weighed and partied for equal six empirical groups, that the 1^st group fed the control diet (without any addition), the 2^nd, 3^rd and 4^th groups were allowed to diets contained 0.50, 1.0 and 1.50% GS, respectively, while the 5^th and 6^th groups were used the control diet boosted with 150 and 300 mg BHT /kg, respectively during fattening period (1-35 day of age). Results indicated that, feeding on diets contained different GS and BHT levels recorded the best productive traits within the entire fattening period (1-35 d-old). Chicks fed diet contained GS had higher (P<0.001) values of hemoglobin, white blood cells and lymphocytes (L) compared to the control, while heterophils (H) and H/L ratio were lowered (P<0.001). Total cholesterol and triglycerides were significantly attenuated of chick's serum by GS and BHT diets. Total antioxidant capacity (TAOC), super oxide dismutase (SOD), catalase (CAT) and glutathione (GSH) concentration were elevated (P<0.001) in serum by feeding 1.0 and 1.50 GS % diets than those of the control, while, malondialdehyde (MDA) was attenuated (P<0.001). Liver tissue content from TAOC, SOD, GSH and CAT enzymes were (P<0.001) enhanced for chicks fed GS diets than those fed BHT and the control diets, however, MDA was attenuated (P<0.001). Economic efficiency was improved (P<0.001) by adding GS to broiler diets flowed by BHT compared with the control group, the best value was occurred with 1.0%GS diet. Using 1.0% grape seeds powder (as a natural antioxidants) in broiler chicks diet could be used to improve the productive, physiological and antioxidants status , economic efficiency as well as decrease the oxidative stress in comparison with BHT (as a synthetic antioxidants) addition for chicks during fattening period.