A total number of 270 local Sinai chicks 1-day-old were weighed and divided into six dietary treatments to determine the nutritional requirements of crude protein (CP) and metabolizable energy (ME) on growth performance during the starter period (1-6 weeks of age) and subsequent effect during grower and laying period from 7 to 32 weeks of age. The dietary levels of CP and ME included 3x2 factorial design (17, 18 and 19 CP, each contained 2850 and 2900 ME). Results of the current study illustrated that the chicks fed starter diet containing 18 and 19% CP recorded significantly (P≤0.05) higher final BW and BWG than those fed diet contained the low level of CP (17%). The most remarkable result is that the heaviest records of BW and daily WG for chicks fed starter diet contained 19% CP and 2850 Kcal/kg diet. It is clearly observed that increment CP level to 18% resulted in a significant (P≤0.05) improved in feed conversion ratio compared to the low level of CP (17%). Feeding on starter diet contained 18% CP + 2900 Kcal/kg diet recorded the best value of viability where it reached to 95.56%. Both HDL and LDL significantly (P≤0.05) increased due to increasing ME from 2850 to 2900 Kcal/kg diet. Sinai birds fed diet contained 17% CP+2850 Kcal/kg diet and19 % CP+2850 Kcal/kg diet reached to SM earlier (143 and 144 d) respectively compared to the other dietary groups. It is evident that egg number and egg mass significantly (P≤0.05) increased when starter diet containing 19% CP compared to the other different levels of CP (17 and 18% CP). While, decreasing dietary ME level to 2850 Kcal/kg in starter diet showed a significant (P≤0.05) improve in egg number and egg mass. Hatchability of set and fertile eggs % of hens fed starter diet contained 2850 Kcal/kg diet was 86.5 and 89.7%, respectively which was significantly (P≤0.05) higher than those fed starter diet with 2900 Kcal/kg diet. No significant effect of dietary two levels of ME in the starter diet on chick weight at hatch could be detected.      The current study has illustrated that the starter diet contained CP 19 % + ME 2850Kcal / kg  diet achieved optimal utilization to protein and energy for Sinai chicks aged between 1 and 6 weeks of age and subsequent effect during the laying period from 21 to 32 weeks of age.