Background and aim of the work: Breast cancer (BC) is the most prevalent 
type of cancer among Egyptian women. This study was undertaken to evaluate 
the clinic-pathological profile of BC patients at South Egypt Cancer Institution 
(SECI), a tertiary-care cancer center at Upper Egypt.
Methods: This one year prospective study included all BC patients registered at 
our institution from the first of February 2022 up to the end of January 2023. All 
studied participants were subjected to detailed data collection about 
demographic, clinical, pathological characteristics, and treatment details. 
Results: We included 75 adult females with newly diagnosed non-metastatic 
BC, with a mean age of 47.05±11.94 years (range; 25- 74 years). The majority 
of the studied cases (76%) underwent modified radical mastectomy (MRM). 
Infiltrating ductal carcinoma (92.0%) was the most common histopathological 
subtype. 69.3% and 30.7% had tumor grade 2 and 3 respectively. Patients had 
relatively large tumors at presentation (> 2 cm in 84% of patients). Positive 
nodal metastasis was documented in 82.7% patients. As regard to biological sub 
types; luminal A, luminal B (HER2-positive), luminal B (HER2-negative), 
HER2 amplified and triple negative breast cancer was found in 33.3%, 25.3%, 
16%, 12% and 13.3% respectively. 52.0% positive for lymphovascular invasion, 
and 62.7% positive for perineural invasion. The TNM (AJCC-7th edition) stage 
distribution was stage I (4.0%), stage II (49.3%), and stage III, (46.7%). During 
the study period 11 cases (14.7%) show disease progression and one case 
(1.3%) died.
Conclusion: This is a comprehensive data from a single tertiary-care cancer 
center in Egypt. Thus, dominance of young age and positive nodal metastasis at 
diagnosis represented the two main features of BC among studied Egyptian 
women. There is a great need for ongoing public health education programs to 
enhance awareness about cancer and encourage for national BC screening 
program.