Introduction: The Pleomorphic adenoma (PA) is the most common benign tumor of salivary glands. It can involve both
major and minor salivary glands. Among minor salivary glands, lips are uncommon sites.
The aim: to warn clinicians regarding diagnosis of unusual upper lip swellings and to describe its clinical and
histopathological features.
Case report: We present a 24-year-old male patient with a pleomorphic adenoma located in the upper lip, which was
discovered accidentally during a medical examination. Surgery was undertaken; the excision of the lip mass was large.
The histopathological examination confirmed the diagnosis. The evolution was favorable with no recurrence during 28
months.
Conclusion: Pleomorphic adenoma of the lip is a rare neoplasm. A complete wide surgical excision is the treatment of
choice. Recurrence after many years of surgical excision as well as malignant transformation should be a concern and
therefore long-term follow-up is necessary.