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294749

.Silver Nanoparticles Attenuate Inflammation aggravation in Hepatocellular Carcinoma in Rats.

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Last updated: 23 Dec 2024

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Abstract

Using silver nanoparticles is a promising tactic in healthcare and cancer therapy, either alone or as an adjuvant in traditional chemotherapy. Also, using gamma radiation in nanoparticle preparation is simple, powerful, and environmentally friendly. This study aimed to assess the impact of silver nanoparticles (AgNPs) prepared by gamma radiation (γ-radiation) on hepatocellular carcinoma (HCC) induced by diethyl-nitrosamine (DEN). MTT Cytotoxicity assay of AgNPs has been detected in vitro on Wi38 normal fibroblast and HepG2 hepatocellular carcinoma cell lines. Twenty-eight adult male albino rats were divided into four groups. After HCC development, rats received (10µg/g b. wt.) of AgNPs, three times a week for four weeks liver enzymes were investigated. TNF-α, TGF-β, and IL-1β inflammatory markers were detected. Also, the transcriptional factor (NF-κB) was calculated. The obtained results confirmed the selective influence of AgNPs on the HCC cell line in a time and dose-dependent manner. Moreover, the role of AgNPs is documented in diminishing the inflammation accompanied by HCC development through decreased inflammatory markers and increased apoptosis.

DOI

10.21608/ajnsa.2023.180669.1698

Keywords

Hepatocellular carcinoma, silver nanoparticles, gamma radiation, diethyl-nitrosamine

Authors

First Name

mahmoud

Last Name

refaat

MiddleName

-

Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt

Email

mahmoud.refaat09@yahoo.com

City

-

Orcid

-

First Name

Shadia

Last Name

Fathy

MiddleName

-

Affiliation

Biochemistry department, faculty of science, Ain Shams University, Cairo, Egypt

Email

shadiafathy2000@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Ragaa

MiddleName

-

Affiliation

Biochemistry department, faculty of science, Ain Shams University, Cairo, Egypt

Email

rmohamed_99@yahoo.com

City

-

Orcid

-

First Name

soheir

Last Name

osman

MiddleName

-

Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt

Email

soheirelboushy@outlook.com

City

-

Orcid

-

First Name

Amany

Last Name

Raafat

MiddleName

-

Affiliation

Chemistry Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority (AEAE), P.O. Box 29, Nasr City 11731, Cairo, Egypt

Email

ismaelraafat_a@hotmail.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Hassan

MiddleName

-

Affiliation

Department of Radiation Biology, National Center of Radiation Research and Technology, Atomic Energy Authority, Egypt

Email

asmaabubakr98@yahoo.com

City

-

Orcid

0000-0002-4424-6278

Volume

56

Article Issue

4

Related Issue

42139

Issue Date

2023-07-01

Receive Date

2022-12-13

Publish Date

2023-07-01

Page Start

73

Page End

80

Print ISSN

1110-0451

Online ISSN

2090-4258

Article File

AJNSA_Volume 56_Issue 4_Pages 73-80.pdf

PDF . 715.5kB

Link

https://ajnsa.journals.ekb.eg/article_294749.html

Detail API

https://ajnsa.journals.ekb.eg/service?article_code=294749

Order

294,749

Type

Original Article

Type Code

455

Publication Type

Journal

Publication Title

Arab Journal of Nuclear Sciences and Applications

Publication Link

https://ajnsa.journals.ekb.eg/

MainTitle

.Silver Nanoparticles Attenuate Inflammation aggravation in Hepatocellular Carcinoma in Rats.

Details

Type

Article

Created At

23 Dec 2024