Background and Purpose: Medical consultants face significant job-related stress due to various factors such as intense workloads and long working hours. This study aimed to assess the job-related stress among medical consultants in Egypt and explore the underlying factors. Methods: A cross-sectional study was conducted, and data were collected using an online questionnaire distributed through social media platforms. The sample consisted of 106 medical consultants residing and working in Egypt. Descriptive statistics and regression analysis were employed for data analysis. Results: The findings revealed that medical consultant's job-related stress varies from high to low level with 25.5% of the studied sample experienced high job-related stress. The stress underlying factors were mainly attributed to low income being the highest stress factor, followed by bureaucratic procedures and managerial responsibilities. Surgical specialties, long working hours, and absence of daily leisure time were positive predictors for high stress levels (p < 0.05). Conclusion: The study highlighted the medical consultants' sufferings from job related stress in Egypt which necessitates the importance of developing tailored interventions to alleviate stress and promote the well-being of medical consultants. Furthermore, addressing these specific stressors can contribute to enhancing the overall Egyptian healthcare system, benefiting both medical consultants and the patients they serve.