Frankincense (Gum Olibanum), made from resins of Burseraceae family, grows in Somalia, India and Yemen. Many years ago the oldest doctors used this plant for treatment of many diseases.The main target of this study was to investigate the effect of different levels of Frankincense on rats suffering from chronic renal failure. The experiment was carried out using 35 male albino rats (Sprague-Dawley strain). The rats were randomly divided into two main groups; the first main group (7 rats) fed on basal diet as a negative control group. The second main group (28 rats) fed on diet containing 0.7% adenine (adenine diet) for 4 weeks to induce chronic renal failure. After this period, the rats in the second main group were divided into four subgroups, the first subgroup was fed on basal diet as a positive control group. The other subgroups (2-4) were fed on basal diets supplemented with three levels from frankincense (1%, 2%, and 3%), respectively. Twenty four hours after the experimental period (4 weeks), blood samples were taken for biochemical analyses.The results indicated that using the three levels from frankincense improved the mean values of uric acid, creatinine, Aspartate Amine Transferase (AST), Alanine Amine Transferase (ALT),total cholesterol, total lipids, and triglycerides in serum by usingthe tested diets.The study recommend retesting the use of frankincense on patient with chronic kidney disease.