Micronutrient deficiencies are serious nutritional problems with cognitive, developmental and economic consequences. Supplementation, fortification, biofortification are best cost effective specific interventions dealing directly with the nutrition problems. Egypt has been suffering from many public health significant micronutrient deficiencies for long time. Many programs have been developed and implemented to deal with these problems. The current review presents description of the most common supplementation and fortification programs targeting iron, iodine and vitamin A, tracking its performance, effectiveness and challenges.