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The Nutritional and Biochemical Indicators of Cardiovascular and Chronic Kidney Diseases Patients Compared to a Normal Group

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Last updated: 03 Jan 2025

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Tags

Clinical trials and cohort studies, with an emphasis on methods for assessing dietary exposures

Abstract

Open Access
*Corresponding author: Hanaa H El-Sayed, Nutritional Chemistry and Metabolism Dept., National Nutrition Institute,
  E-mail Hanaa_Hamad2003@yahoo.com
Mobile: +0201008825869
 
Received: 20 April 2024
 Accepted:23 May 2024
 Published online: 14 June 2024
 
Citation
Mohamed MA; Emara AH; Ibrahim NR; Ahmad EM; Abd El-Hamid and El-Sayed HH (2024): The Nutritional and Biochemical Indicators of Cardiovascular and Chronic Kidney Diseases Patients Compared to a Normal Group, BNNI (63) 51 -76. doi. 10.21608/BNNI.2024.360774




Chronic kidney disease (CKD) and cardiovascular disease (CVD) exacerbate each other's progression, increasing morbidity and mortality rates. Studying these interrelated conditions requires strict nutritional and biochemical monitoring. By comparing macro- and micronutrient intake to the recommended daily intake (RDI), biochemical tracking provides valuable information about metabolic diseases, aiding early diagnosis and tailored treatment regimens. This study involved 60 subjects: 30 healthy controls and 30 patients with CKD and CVD from the outpatient clinic of the National Institute of Urology and Nephrology in Cairo, Egypt. The findings demonstrated that macronutrient intake in both groups was lower than the RDI except for protein. Both groups had inadequate vitamin D (VD) taken, getting smaller than 50% of the RDI, with significant differences noticed in serum VD levels, which were less in the CKD+CVD group. Except for sodium intake, higher than the RDI in both groups, all mineral intakes were below the RDI, with magnesium and potassium intake less than 50% of the RDI. Biochemical markers of renal mission, except for the estimated Glomerular Filtration Rate (eGFR), were lower than normal in the patient group. The patient group had greater concentrations of cardiac markers such as creatine kinase, troponin, lactate dehydrogenase (LDH), and vascular cellular adhesion molecule-1 (VCAM-1). Their lipid profile showed significant increases in triglycerides, low-density lipoprotein (LDL-C), very LDL-C, atherogenic index (AI), and atherogenic coefficient (AC), while high-density lipoprotein (HDL-C) levels significantly decreased. This study emphasizes that nutritional intervention and novel biomarkers are crucial for these patients.

DOI

10.21608/bnni.2024.360774

Keywords

Chronic Kidney and Cardiovascular Diseases patient, nutrition, biomarker

Authors

First Name

Mona

Last Name

Mohamed

MiddleName

A

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

Email

-

City

Cairo

Orcid

-

First Name

Amal

Last Name

Emara

MiddleName

H

Affiliation

Nutritional Chemistry and Metabolism Department, National Nutrition Institute, Cairo, Egypt.

Email

-

City

Cairo

Orcid

-

First Name

Nehad

Last Name

Ibrahim

MiddleName

R

Affiliation

clinical pathology, National Institute of Urology and Nephrology, Cairo, Egypt

Email

-

City

Cairo

Orcid

-

First Name

Entsar

Last Name

Ahmad

MiddleName

M

Affiliation

Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt

Email

-

City

Cairo

Orcid

-

First Name

Fatma

Last Name

Abd El- Hamid

MiddleName

K

Affiliation

Nutritional Chemistry and Metabolism Department, National Nutrition Institute, Cairo, Egypt.

Email

-

City

Cairo

Orcid

-

First Name

Hanaa

Last Name

Elsayed

MiddleName

H

Affiliation

Nutritional Chemistry and Metabolism Department, National Nutrition Institute, Cairo, Egypt.

Email

hanaa_hamad2003@yahoo.com

City

Cairo

Orcid

0000-0003-0443-0940

Volume

63

Article Issue

1

Related Issue

46793

Issue Date

2024-06-01

Receive Date

2024-06-13

Publish Date

2024-06-01

Page Start

51

Page End

76

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 63_Issue 1_Pages 51-76.pdf

PDF . 846.6kB

Link

https://bnni.journals.ekb.eg/article_360774.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=360774

Order

360,774

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

The Nutritional and Biochemical Indicators of Cardiovascular and Chronic Kidney Diseases Patients Compared to a Normal Group

Details

Type

Article

Created At

23 Dec 2024