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310139

Evaluation The Ameliorative Effect of Alcoholic Extracts of Citrullus colocynthis and Phyllanthus Emblica Fruits on Streptozotocin-Induced Diabetes in Male Rats

Article

Last updated: 23 Dec 2024

OverviewSimilar Items

Subjects

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Tags

Food and quality control

Abstract

Diabetes mellitus (DM) is a serious health issue for the general public. In this work, male diabetic rats were used to determine the impact of Citrullus colocynthis and Phyllanthus Emblica fruits ethanolic extract (EECC and EEPE). Six groups of thirty mature rats (male Sprague Dawley) were examined. In the first group, normal rats have been fed a balanced diet served as the negative control group (C-); in the second group, diabetic rats served as the control positive (C+). Diabetic rats in groups 3, 4, 5, and 6 received daily treatments of (200 and 400 mg kg-1 body weight (BW) EECC and EEPE, respectively. After four weeks of treatment, Biochemical indicators were examined in all blood samples. Streptozotocin was injected and resulted in a significant reduction in feed intake (FI), feed efficiency (FER) body weight gain (BWG), serum insulin, high-density lipoprotein (HDL-c), globulin, albumin, and total protein, as well as antioxidant enzymes, glutathione (GSH) and superoxide dismutase (SOD) in pancreatic tissue, whereas a significant increment was noted in serum glucose, triglyceride (TG), total cholesterol (TC),  low & very low-density lipoprotein cholesterol (LDL-c and VLDL-c), atherogenic index (AI), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), alanine aminotransferase (ALT),  urea,  uric acid, creatinine, tumor necrosis factor-α, creatine phosphate kinase (CPK) and lactate dehydrogenase (LDH) and lipid peroxidation (MDA) in pancreatic tissue. The treatment of diabetic animals with different ethanolic extracts caused improvements in all previously measured parameters, with EEPE (400 mg kg-1 BW) showing the greatest improvement.

DOI

10.21608/bnni.2023.310139

Keywords

Citrullus colocynthis, Phyllanthus emblica, Blood Glucose, Serum Insulin

Authors

First Name

Asmaa

Last Name

EL-Gawish

MiddleName

M

Affiliation

Nutrition and Food Science Dept., Faculty of Home Economics, Al-Azhar University, Egypt-

Email

-

City

Tanta

Orcid

-

Volume

62

Article Issue

2

Related Issue

42671

Issue Date

2023-12-01

Receive Date

2023-07-29

Publish Date

2023-12-01

Page Start

53

Page End

85

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 62_Issue 2_Pages 53-85.pdf

PDF . 741.9kB

Link

https://bnni.journals.ekb.eg/article_310139.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=310139

Order

310,139

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

Evaluation The Ameliorative Effect of Alcoholic Extracts of Citrullus colocynthis and Phyllanthus Emblica Fruits on Streptozotocin-Induced Diabetes in Male Rats

Details

Type

Article

Created At

23 Dec 2024