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291548

The Effect of Tribulus Terrestris Fruits and Urtica dioica Leaves Extracts on Renal Calculus Induced by Sodium Oxalate in Experimental Rats

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

Bioavailability of nutrients and metabolism

Abstract

A common urological disorder is kidney stone formation. Previous research has shown that long-term exposure to oxalate damages renal epithelial cells and stress caused by oxidation. The current investigation evaluated the effect of aqueous extracts of Tribulus Terrestris fruits, and Urtica dioica leaves against renal calculus induced by sodium oxalate in male albino rats. The injection with sodium oxalate (70 mg/kg) intraperitoneally for ten days to cause renal calculi increased serum creatinine, urea, uric acid, and serum electrolytes, urinary electrolytes, urinary components, serum tumor necrosis factor-alpha, as well as malondialdehyde in kidney tissue. A decrease in creatinine clearance and antioxidant enzyme activity (superoxide dismutase and catalase) was observed. Treated groups with Tribulus Terrestris and Urtica dioica aqueous extracts (250 and 500 mg / Kg body weight), respectively, for 28 days improved body weight gain (BWG), Feed intake (FI), feed efficiency ratio (FER), relative kidney weight, kidney functions, serum electrolytes, urinary electrolytes, urinary components, serum tumor necrosis factor-alpha, antioxidant enzymes activity. Histopathological examination confirmed the biochemical analysis. It was concluded that Tribulus Terrestris and Urtica dioica aqueous extracts affect kidney stone modeling caused by sodium oxalate by reducing tissue degeneration and the number of stones because they possess antioxidants.

DOI

10.21608/bnni.2023.291548

Keywords

Tribulus terrestris, Urtica dioica, Sodium Oxalate, kidney functions, Antioxidant enzymes

Authors

First Name

Soha

Last Name

Mohamed

MiddleName

S

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Al Azhar University, Tanta 31732, Egypt

Email

-

City

Tanta

Orcid

-

First Name

Neveen

Last Name

Zeima

MiddleName

M

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Al Azhar University, Tanta 31732, Egypt

Email

-

City

Tanta

Orcid

0000-0002-3497-8811

First Name

Amira

Last Name

El-Melmoslemany

MiddleName

M

Affiliation

Nutrition and Food Science Department, Faculty of Home Economics, Al Azhar University, Tanta 31732, Egypt; Egypt;

Email

-

City

Tanta

Orcid

0000-0003-4159-1161

Volume

61

Article Issue

1

Related Issue

39752

Issue Date

2023-06-01

Receive Date

2023-03-20

Publish Date

2023-06-01

Page Start

100

Page End

137

Print ISSN

1110-0974

Online ISSN

2537-0987

Article File

BNNI_Volume 61_Issue 1_Pages 100-137.pdf

PDF . 1.4MB

Link

https://bnni.journals.ekb.eg/article_291548.html

Detail API

https://bnni.journals.ekb.eg/service?article_code=291548

Order

291,548

Type

Original Article

Type Code

442

Publication Type

Journal

Publication Title

Bulletin of the National Nutrition Institute of the Arab Republic of Egypt

Publication Link

https://bnni.journals.ekb.eg/

MainTitle

The Effect of Tribulus Terrestris Fruits and Urtica dioica Leaves Extracts on Renal Calculus Induced by Sodium Oxalate in Experimental Rats

Details

Type

Article

Created At

23 Dec 2024