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399219

COPPER NANOPARTICLES AFFECTING APOPTOSIS RELATED GENE EXPRESSION AND THE PROTECTIVE EFFECT OF ALPHA-LIPOIC ACID IN ADULT MALE ALBINO RATS: A CHRONIC STUDY

Article

Last updated: 23 Dec 2024

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Subjects

-

Tags

• Nano toxicology

Abstract

Background: Copper nanoparticles (CuNPs) attract considerable interest because of their specific chemical and physical characteristics. In nanotoxicology, reactive oxygen species are considered the primary underlying chemical process that sets off subsequent processes that can eventually result in cell damage. The antioxidant and metal/toxin chelating properties of alpha-lipoic acid have been shown to have beneficial effects on a broad range of clinical conditions.
Aim of the study: This study aimed to evaluate the effect of copper nanoparticles on cytoplasmic/mitochondrial apoptosis through apoptosis-related genes and to study the potential protective effect of alpha-lipoic acid against apoptosis induced by copper nanoparticles.
Methods: The toxicity was investigated by evaluating the levels of BCL-2 and BAX genes in the liver and kidney tissues of rats using quantitative real-time polymerase chain reaction analysis and evaluating hepato-nephrotoxicity and, oxidative stress markers as well.
Results: CuNPs caused increased expression of BAX gene (cytoplasmic/mitochondrial pro-apoptotic gene) and decreased expression of BCL-2 gene (anti-apoptotic gene) in rats receiving CuNPs compared to the control groups. The use of alpha-lipoic acid had a protective effect when given with copper nanoparticles. However, it had no significant effect when given alone compared to the control groups.

DOI

10.21608/ejfsat.2024.316786.1348

Keywords

Copper nanoparticles, Nanotoxicity, Apoptotic genes, Oxidative Stress, alpha-lipoic acid

Authors

First Name

Marwa

Last Name

Mohamed

MiddleName

Issak

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

missak1978@hotmail.com

City

Cairo

Orcid

0000-0002-8026-6858

First Name

Rabab

Last Name

Eltokhy

MiddleName

Abdulmoez

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

drrabababdulmoez@gmail.com

City

Cairo

Orcid

0000-0002-0666-5949

First Name

Mervat

Last Name

Abdelsalam

MiddleName

Hamdy

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine , Cairo University, Cairo, Egypt

Email

mervathamdy@hotmail.com

City

Cairo

Orcid

0000-0002-6365-332X

First Name

Eman

Last Name

El-Zohairy

MiddleName

Abdelfattah

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

emanzohairy@hotmail.com

City

Cairo

Orcid

-

First Name

Laila

Last Name

Rashed

MiddleName

Ahmed

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

lailaahmedrashed@gmail.com

City

-

Orcid

-

First Name

Nada

Last Name

Abdel-raof

MiddleName

Elsayed

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

naada.selim@gmail.com

City

Cairo

Orcid

0000-0001-7762-7264

First Name

Mai

Last Name

Mahrous

MiddleName

Mohamed

Affiliation

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

mai_mahrous2@kasralainy.edu.eg

City

-

Orcid

0000-0003-1472-4686

Volume

24

Article Issue

4

Related Issue

51926

Issue Date

2024-12-01

Receive Date

2024-09-05

Publish Date

2024-12-01

Page Start

17

Page End

29

Print ISSN

1687-0875

Online ISSN

2535-1915

Article File

EJFSAT_Volume 24_Issue 4_Pages 17-29.pdf

PDF . 607.2kB

Link

https://ejfsat.journals.ekb.eg/article_399219.html

Detail API

https://ejfsat.journals.ekb.eg/service?article_code=399219

Order

399,219

Type

Original Article

Type Code

429

Publication Type

Journal

Publication Title

The Egyptian Journal of Forensic Sciences and Applied Toxicology

Publication Link

https://ejfsat.journals.ekb.eg/

MainTitle

COPPER NANOPARTICLES AFFECTING APOPTOSIS RELATED GENE EXPRESSION AND THE PROTECTIVE EFFECT OF ALPHA-LIPOIC ACID IN ADULT MALE ALBINO RATS: A CHRONIC STUDY

Details

Type

Article

Created At

23 Dec 2024