Background: Paraquat dichloride, a widely used herbicide, poses health and environmental risks due to its wide range of use in the modern-day Argo life, endangering aquatic life, farm animals, rodents and human health particularly, liver-related ailments, the aim of the study is to evaluate the effect of paraquat on the liver of pregnant Wistar rats at various trimesters. Material and Method: The study involved 24 pregnant Wistar rats divided into four groups: A (control), B, C and D (treated with 1mg/kg, 5mg/kg, 10mg/kg concentration of paraquat dichloride) each group comprised six rats. Throughout each trimester, two rats from each group were euthanize on day 7, 14, and 21 respectively. The concentrations (1mg/kg, 5mg/kg, 10mg/kg) were chosen below the lethal dose of 50mg/kg to induce graded dose histological changes in the liver. Result: The liver tissue initially appeared normal at day 7 across all group with varying doses. However, by day 14 and 21, significant histological changes were observed, such as central vein congestion, hemorrhages, degenerative changes, and bile duct hyperplasia. Conclusion: These finding highlight the changes that occurs with varying doses of paraquat exposure in the liver as pregnancy progresses in Wistar rats.