Introduction: Organ transplantation started in 1954. Improvements in organ transplantation have made progress to save many people suffering from end-stage organ failure because organ transplantation is the treatment of choice for most end-stage organ failure diseases. Objectives: Although physicians can affect attitudes toward organ donation in society, few studies about the attitudes of these Egyptian physicians toward organ donation have been conducted in Egypt. Therefore, the objective of our study was to assess the ethical knowledge and perceptions of doctors regarding organ donation methods. In our research, we used the online Google form, which was distributed throughout Facebook and Whats' app (the two most popular social media platforms), to ensure a high rate of response. The researchers shared the link of the survey along with the explanation of its purpose to encourage the participants. Calculations of correct responses were coded as 1, and correct and unknown responses were coded as 0. (18 questions, maximum score 18, minimum score 0). The percent score was calculated as: individual response/maximum score 18 *100. Results: A total of 247 physicians participated in the survey, and the mean age of the participants was 36 years (standard deviation ±4. A total of 89.9% of the respondents had clinical specialties, and 44.5% had master's degrees. The majority of the participants (n=149, 81.9%) had not read about the law regulating organ transplantation. A total of 74 (40.7%) of them knew about the law from media, 53 (29.1%) knew about the law from practice, 43 (23.6%) knew about the law from study, and 12 (6.6%) of participants knew about the law from other resources. A total of 137 responders had poor knowledge, 110 had good knowledge about OD, and more knowledge was among surgeons. Among the 247 participants, 44.5% had an average knowledge score and suboptimal practice score, with a mean knowledge score of 8 ± 3 and a median of 8 (6,10). Conclusion: Most of the participants had poor knowledge. Poor knowledge increased in urban areas in comparison to good knowledge about OD. There was greater knowledge among surgeons. The majority of participants had their knowledge of practice