Background: caffeine, energy drink, cola, cola diet and beer beverages consumed widely all over the world, But its safety is controversial especially if taken regularly in higher amount and in vulnerable groups. Objectives we assess toxicity of Energy drink and Alcohol containing beer on different organs of experimental rats by comparison with Caffeine and Carbonated beverages on brain, liver, testis, kidneys and heart of experimental rats by using both laboratory and histopathological methods. Methodology in our study thirty mature male rats were assigned into 6 groups A-F of 5 rats per Group as follow, control group, high dose of caffeine, cola beverage, diet cola beverage, energy drink beer 4.5% intake groups for 4 weeks via oral route. Bilirubin, AST, ALT, Albumin, urea, creatinine, CK, CK-MB, LDH and testosterone level in blood was assessed at start and in day 28, After rats sacrificed brain, liver, testis, kidneys and heart tissues taken for histopathological examination. Results: Liver enzyme ALT, AST and LDH is higher than normal in beer and energy drink beverages groups by comparison with other groups; CK is high in energy drink beverages group by comparison with other groups. However, total testosterone is low in beer group by comparison with other groups; also, we found Histopathological changes in liver in energy drink beverages group. Conclusion energy drink beverages intake on high amount are hazardous on heart and liver of albino rats, Beer is hazardous on liver functions tests and lower Total testosterone level in Albino rats.