Background: Medical malpractice is a legal cause of action that arises when a doctor deviates from the accepted norm and results in a patient's decline or death. MEs continue to be a serious global concern in developing nations like Egypt, where resources are scarce, so more high-risk. Physicians must demonstrate real, compensable injuries to fulfill their ethical responsibility to provide care to their patients. Despite the rare data on ME in Egypt, continues to be a significant cause for worry. Maintaining a culture that strives to identify safety issues and put workable solutions in place rather than supporting a culture of blame, guilt, and punishment is one way to address the MEs problem. Objective The purpose of the current study is to identify ME cases among Egyptian physicians and assess their level of knowledge regarding MEs and the law. It also seeks to identify the specializations where ME is most frequently made. Analyzing the recurrence of ME and its primary causes is another crucial objective, followed by the development of effective preventative measures. Methods: To ensure diversity in specializations and cultural backgrounds, the authors created a questionnaire and sent it online to 200 Egyptian physicians from various areas and governorates in Egypt. Results: In this study, there were a total of 200 participants, consisting of 80 men and 120 women. The age groupings included those with the highest percentage (4.4%) over 40 years old, 61.3% between 30 and 40 years old, and 34.4% between 24 and 30 years old. They were divided into three categories: internal medicine, surgery and its subspecialties, and paramedical with their many specialization. The younger age groups committed ME at higher rates than the older age group, Men had a larger percentage of ME than women. Among the other specializations, internal medicine and paramedical specialties had the lowest rate of MEs, followed by surgery and its branches. Conclusion: Age, sex, and medical specializations of physicians were related to the frequency of ME. In order to manage ME, medical education be expanded; and most experienced doctor should be present.