Impairment or disability is an important legal and medical issue. Road traffic accidents, torture, assaults and occupational adversity are the main causes for permanent infirmity occurrence, but traffic accidents are the most frequent cause. Aim: This work aimed to study the pattern of permanent infirmities cases examined at Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Menoufia University. Patients & methods: This study was conducted on all cases examined at forensic medicine and clinical toxicology department, faculty of medicine, Menoufia university for obtaining final reports with final diagnosis of definite permanent infirmities over two years (2021 (a retrospective part) and 2022 (a prospective part)). Permissions were obtained from the Ethics Committee of Menoufia University Hospital and from the head of forensic medicine and clinical toxicology. Results: This study was conducted on 264 cases. Most of them Males were (72%), in the age group 18- 40 years, from rural regions, had basic level of education, manual workers and most cases were occurred accidentally. Most injuries were caused by blunt instruments (63.3%), followed by sharp instrument (34.8%). Regarding circumstances, road traffic accidents (RTA) were the most common (48.9%) followed by assault (35.2%). Recommendations: Attention should be applied to application of strict regulations and laws. In addition, the study recommends enhancement and maintenance of roads and safety measures should be applied to workplaces and manual workers specially those involved in construction industry should use safety equipment.