Background: Global climate change (GCC) is on the point of altering the degree of human exposure to poisons and the response of hominoid populations to these contacts, meaning that risks of pollutants could change in the future. In certain parts of the world, GCC is foretold to increase the level of exposure to many environmental contaminants due to direct and indirect belongings on the use designs and transport, and destiny of chemicals. Changes in human performance will also affect human contact way with contaminated air, water, and food. Psychosocial stress, dietary changes, and contact with stressors as high temperatures are likely to increase the susceptibility of humans to chemicals. These changes are likely to have important inferences for current practices for chemical assessment. Traditions used in current exposure-assessment replicas may no longer apply, and existing checking methods may not be vigorous enough to detect adverse sporadic changes in exposures. Aim of the work: The present review article explores how GCC might touch the different ladders in the pathway from a chemical source in the environment through to impacts on human health and assesses the proposals for current risk assessment and management practices. Methodology: Articles were assembled using convenient keywords through Google Scholar, PubMed, Egyptian Knowledge Bank (EKB), Wiley Online Library, and Web of Science. Inclusion criteria: peer-reviewed studies, meta-analytic and narrative reviews, and WHO reports published in the era between 1995 and 2022. Exclusion criteria: online articles not allied to a committed database or articles with closed access. Results: more research and studies are needed for prevention GCC