ManageChatDiscover
319211

CLONAZEPAM INDUCED SUB CHRONIC HEPATORENAL TOXICITY IN RATS AND THE PROTECTIVE ROLE OF ALPHA-TOCOPHEROL

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Background: Clonazepam (CZP) is an antiepileptic drug approved in 1976 by Food and Drug Administration (FDA) for treatment of various types of seizures, Clonazepam has a high potential for abuse, as well as tolerance, physical dependence, and ultimately addiction. Although many studies confirmed the deleterious effects of other antiepileptic like valproic acid and carbamazepine, those of clonazepam are minimal. Objectives: This research aimed to study and evaluate the hepatotoxic and nephrotoxic effects of sub chronic high dose administration of clonazepam and the protective effect of alpha-tocopherol “vitamin E" (V.E). Methods: Forty (40) healthy male albino rats were included. They were randomly divided into four equal groups (10 rats each): group I (normal saline), group II (CZP misuse), and group III (V.E) and group ΙV (CZP + V.E). All rats received the commenced drugs for 50 days. Serum levels of AST, ALT, ALP, urea, creatinine and uric acid were measured. Liver and kidney tissues were taken for histopathology. Results: clonazepam in high doses increased hepatic and renal biomarkers levels, disrupted hepatic and renal tissues and increased the number of degenerated cells. V.E treatment significantly attenuated the deleterious effects induced by clonazepam.

DOI

10.21608/ejfsat.2023.205239.1289

Keywords

Keywords: Clonazepam, misuse, Hepatotoxicity, Nephrotoxicity, alpha-tocopherol, Rats

Authors

First Name

nada

Last Name

Abdel-raof

MiddleName

elsayed

Affiliation

department of forensic medicine and clinical toxicology cairo university

Email

naada.selim@gmail.com

City

cairo

Orcid

0000-0001-7762-7264

First Name

Mahmoud

Last Name

Khattab

MiddleName

Ahmed

Affiliation

Department of Medical Pharmacology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

mahmoudkhattab@kasralainy.edu.eg

City

-

Orcid

-

First Name

Fatma

Last Name

Abdel Maksoud

MiddleName

Abdel Wahab

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

Email

fatma.abdelwahab@kasralainy.edu.eg

City

-

Orcid

-

First Name

Maha

Last Name

Emad Eldein

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

mahaemadeldein@kasralainy.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Elshatory

MiddleName

-

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

ahmedelshatory@cu.edu.eg

City

-

Orcid

-

First Name

Walaa

Last Name

Awad

MiddleName

-

Affiliation

Clinical Pharmacy Department, Abo El-Reesh Al Mounira Hospital, Cairo University, Cairo, Egypt

Email

walaaawad83@yahoo.com

City

-

Orcid

-

First Name

Mohammad

Last Name

El-Kattan

MiddleName

Abd-El-Samee

Affiliation

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

mohtan_84@yahoo.com

City

-

Orcid

0000-0002-8957-4531

Volume

23

Article Issue

3

Related Issue

43090

Issue Date

2023-09-01

Receive Date

2023-05-04

Publish Date

2023-09-01

Page Start

77

Page End

95

Print ISSN

1687-0875

Online ISSN

2535-1915

Article File

EJFSAT_Volume 23_Issue 3_Pages 77-95.pdf

PDF . 2.2MB

Link

https://ejfsat.journals.ekb.eg/article_319211.html

Detail API

https://ejfsat.journals.ekb.eg/service?article_code=319211

Order

319,211

Type

Original Article

Type Code

429

Publication Type

Journal

Publication Title

The Egyptian Journal of Forensic Sciences and Applied Toxicology

Publication Link

https://ejfsat.journals.ekb.eg/

MainTitle

CLONAZEPAM INDUCED SUB CHRONIC HEPATORENAL TOXICITY IN RATS AND THE PROTECTIVE ROLE OF ALPHA-TOCOPHEROL

Details

Type

Article

Created At

23 Dec 2024