Objectives: The purpose of this study was to assess the effect of management on the outcome of antipsychotic drugs overdose in Egypt.
Methodology: This study was conducted on 75 cases presented to National Environmental and Clinical Toxicology research Centre, Cairo university hospitals with antipsychotic medications toxicity, from April 2018 to September 2018.
Results: The most common presenting age group was age group B; from 18-40 years (45.3%), females (68%), belonging to urban population (82.7%), educated (96.2%) and not working (89.3%). The majority of cases presented with abnormal CNS manifestation; altered conscious level (97.3%), abnormal pulse; tachycardia (98.7%) and abnormal pupil size; mydriasis or miosis (52%). Most of the cases did not do drug screening (98.7%), neither did decontamination (66.7%) nor receive antidote (100%), but most of them received supportive measures. Most of the cases were admitted (90.7%) and stayed in hospital more than 24 hours and less than one week. Regarding the outcome, most of the cases were cured (92.6%).