Medical ethics and research ethics are essential for clinical practice and for achievement of the balance between advancement in science and protection of human subjects' rights. The aim of the study is to assess the effects of implementing a short course on medical and research ethics at the Faculty of Medicine, Zagazig University. Design: An interventional study was done at Zagazig University Hospitals. Sample: The study sample consisted of 108 residents working in Zagazig University Hospitals. Tools: Data was collected through an interviewing questionnaire to assess sociodemographic characteristics of the residents, their medical and research ethics knowledge and attitude before and after the intervention course. Results: the residents included the study had deficient knowledge and attitude about medical and research ethics. The implementation of educational intervention course was effective in improving their knowledge and attitude toward medical and research ethics. The total satisfactory knowledge and attitude towards medical ethics showed high statistically significant improvements after the intervention ( 63.9% and 60.2%) respectively compared with (22.2% and 35.1%) respectively before intervention( p < 0.001). Also, there were high statistically significant improvements in total knowledge and attitude towards research ethics after the intervention (83.3% and 72.2%) respectively compared with (19.4% and 19.4%) respectively before intervention p < 0.001) . Conclusion and Recommendations: Knowledge and attitudes of residents towards medical and research ethics found to be inadequate. Educational intervention programs about medical and research ethics are in need to be apriority and repeated medical and research ethics courses should be integrated within the postgraduate curriculum.