Background: Due to the legal implications and taboo nature of the subject, there remains a lack of knowledge surrounding paraphilia and bestiality. Many people interact with animals in their daily lives, either indoors or away from home. Close contact with animals, particularly in psychologically disturbed individuals, may lead to extreme feelings, which may lead to sexual contact between humans and animals. Sexual abuse of animals has been known since ancient times. Aim: the current systematic review presented the possible role of technology to promote sexual addiction, particularly among children, the role of porn film imageries to normalize animal-human sex, the hidden danger of paraphilia to threatens human health, and an excerpt history of the originality of sexually transmitted zoonotic pathogens. We also inquired about the potential of zoonotic diseases to spread, their vertical transmission, and how normal productivity in humans can be affected. The role of symbiosis in sexually transmitted diseases was also presented. Methods: Google Scholar, PubMed, and Egyptian Knowledge Bank were searched using the keywords paraphilia, zoophilia, bestiality, and zoonotic disease. Conclusions: Bestiality remains obscured. Normalization of bestiality and the subsequent spread of sexual zoonosis is a figure of bioweapon. The hidden role of the internet to spread bestiality should be regarded.