297696

TOXIC EFFECTS OF CHRONIC USE OF GIBBERELLIC ACID ON LIVER AND KIDNEY AND HEMATOLOGICAL STUDY IN MALE ALBINO RATS

Article

Last updated: 03 Jan 2025

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Abstract

Introduction: Many chemicals are currently used in agriculture among which plant growth regulators are widely employed. Gibberellic acid (GA3) plays important roles in many cellular processes including promoting stem elongation, and mobilization of food reserves in grass seed germination, juvenility, and sex expression. The aim of the work: To detect the possible chronic toxic effects of gibberellic acid on liver and kidney and effect on hemoglobin and blood glucose levels. Methodology: the sample rats were divided into four equal groups of animals. The first group is control group (group G1). The remaining three groups received different doses of gibberellic acid (group G2 received 1/10 of LD50), Group G3 received 1/100 of LD50, Group G4 received 1/200 of LD50). Each group was subdivided into 2 subgroups: The first subgroup (A) containing 10 rats that were treated with gibberellic acid orally by gavage for 12 weeks then salvaged for histopathology. The second subgroup (G2R, G3R and G4R) containing 5 rats that were kept after the treatment for recovery period for 2 weeks to detect its cumulative effect. The rats of each group were weighed at the beginning of the experiment then every week for 12 weeks, the change in body weight was calculated. Repeated blood samples were collected for measuring hemoglobin and blood glucose level. Then 10 rats from each of the four groups were sacrificed by decapitation.

DOI

10.21608/zjfm.2023.183873.1137

Keywords

Gibberellic, acid, Oxidative Stress

Authors

First Name

Amany

Last Name

Bayoumy

MiddleName

Abdelfattah

Affiliation

faculty of medicine ,cairo university

Email

dr_amaniforensic@yahoo.com

City

Cairo

Orcid

-

First Name

Mervat

Last Name

Abd El Salam

MiddleName

Hamdy

Affiliation

faculty of medicine ,cairo university

Email

mervathamdy@hotmail.com

City

Cairo

Orcid

-

First Name

abla

Last Name

ali

MiddleName

Abd El Rahman

Affiliation

kasr aleiny faculty of medicine

Email

ablaali410@gmail.com

City

-

Orcid

-

First Name

Randa

Last Name

El Shenawy

MiddleName

Mohey El Din

Affiliation

faculty of medicine ,cairo university

Email

drmokhtar@hotmail.com

City

CAIRO

Orcid

-

First Name

Olfat

Last Name

Radwan

MiddleName

Abd El Latif Sayed

Affiliation

Toxicology - Pesticides Analysis Department, Central Agricultural Pesticide Lab (CAPL)

Email

mokhtar.fathy@kasralainy.edu.eg

City

-

Orcid

-

First Name

Mai

Last Name

Magdi

MiddleName

Moustafa

Affiliation

lecturer of forensic medicine and clinical toxicology, Faculty of medicine, Cairo University

Email

dr.maimagdi_83@kasralainy.edu.eg

City

CAIRO

Orcid

0000-0003-3944-8008

Volume

21

Article Issue

1

Related Issue

37542

Issue Date

2023-01-01

Receive Date

2023-01-02

Publish Date

2023-01-01

Page Start

208

Page End

222

Print ISSN

1687-160X

Online ISSN

2536-9849

Link

https://zjfm.journals.ekb.eg/article_297696.html

Detail API

https://zjfm.journals.ekb.eg/service?article_code=297696

Order

1

Type

Original Article

Type Code

402

Publication Type

Journal

Publication Title

Zagazig Journal of Forensic Medicine and Toxicology

Publication Link

https://zjfm.journals.ekb.eg/

MainTitle

TOXIC EFFECTS OF CHRONIC USE OF GIBBERELLIC ACID ON LIVER AND KIDNEY AND HEMATOLOGICAL STUDY IN MALE ALBINO RATS

Details

Type

Article

Created At

23 Dec 2024