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Can Maternal Serum High Sensitivity C-Reactive Protein Predict Outcome of Threatened Miscarriage?

Article

Last updated: 03 Jan 2025

Subjects

-

Tags

Medicine

Abstract

Background: Subclinical systemic inflammation may impede maternal immune tolerance, and implantation and embryonic development might be compromised. Inflammation could also be a causative factor for a proportion of miscarriages. As inflammatory reactions have a role in the occurrence of miscarriage, threatened miscarriage may be associated with higher maternal serum levels of High Sensitive - C reactive protein (HS-CRP) than in average, uncomplicated pregnancy.
Objective: To assess the accuracy of maternal serum (hs-CRP) in predicting pregnancy outcomes in women presenting with threatened miscarriage.
Study Design: Observational prospective cohort study included 200 pregnant women seeking antenatal care subdivided into two equal groups; Study group: 100 women with threatened miscarriage (presented by bleeding in early pregnancy, and Control group: 100 women with an uneventful pregnancy. All 200 pregnant women were under close follow-up every two weeks for vaginal bleeding and ultrasound assessment. For the quantitative measurement, maternal serum hs-CRP levels were evaluated by the Enzyme-Linked Immunosorbent Assay (ELISA) Kit.
Results: The mean serum level of HS-CRP (mg/dl) was significantly elevated in the study group (threatened miscarriage group) (8.73±1.55) than in the other group (5.17±2.04) in the control group (P<0.001). Miscarriage occurred in a more significant proportion in the study group (threatened miscarriage group) (40%) than their counterparts (10%) (P<0.001).
Conclusions: Maternal serum HS-CRP's levels were significantly higher in threatened miscarriage women than in average, uncomplicated pregnant women. This investigation suggests that pregnancy loss and chronic inflammation occur in association, so the relation between inflammation and pregnancy outcomes needs further investigation.

DOI

10.21608/ebwhj.2022.145356.1183

Keywords

hs-CRP, first trimester, Miscarriage, pregnancy outcome, Threatened Abortion

Authors

First Name

rehab

Last Name

aboshama

MiddleName

A

Affiliation

ain shams

Email

rehab.aboshama@yahoo.com

City

cairo

Orcid

0000-0001-7765-1301

First Name

Kareem

Last Name

El-Nahhas

MiddleName

-

Affiliation

Department of Reproductive Health Research, National Research Centre, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

Zaatar

MiddleName

-

Affiliation

Department of Reproductive Health Research, National Research Centre, Egypt

Email

-

City

-

Orcid

-

First Name

Laila

Last Name

Abdelfattah

MiddleName

Ezzat

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Egypt

Email

-

City

-

Orcid

-

Volume

14

Article Issue

4

Related Issue

51563

Issue Date

2024-11-01

Receive Date

2022-06-22

Publish Date

2024-11-01

Page Start

400

Page End

406

Print ISSN

2090-7265

Online ISSN

2090-7257

Link

https://ebwhj.journals.ekb.eg/article_391822.html

Detail API

https://ebwhj.journals.ekb.eg/service?article_code=391822

Order

391,822

Type

Original Article

Type Code

366

Publication Type

Journal

Publication Title

Evidence Based Women's Health Journal

Publication Link

https://ebwhj.journals.ekb.eg/

MainTitle

Can Maternal Serum High Sensitivity C-Reactive Protein Predict Outcome of Threatened Miscarriage?

Details

Type

Article

Created At

23 Dec 2024