Objectives: Our study aimed to compare the operative outcomes of laparoscopic salpingectomy operations conducted using 3-D and standard 2-D laparoscopic vision systems to determine which is better during surgery.Patients and Methods: This prospective, parallel two-arm single-blinded allocation-concealed randomized controlled trial was conducted at the Obstetrics and Gynecology Department, Cairo University, Egypt. We randomized 36 patients in a 1:1 ratio to the 3-D or 2-D laparoscopy groups. In the 3-D laparoscopy group, salpingectomy was performed using the Storz Image1 S 3-D laparoscopy system. In the 2-D laparoscopy group, salpingectomy was performed using conventional 2-D laparoscopy. At the end of the operation, we recorded the time needed to excise the hydrosalpinx, the total operative time, the estimated intraoperative blood loss, and the surgeon's comfort.Results: When comparing the intraoperative findings of the 3-D and 2-D groups, we found a lower operative time (p-value = 0019), less time for fallopian tube excision (p-value < 0.001), and higher comfort of the surgeon (p-value =<0.0001) in the 3-D group than in the 2-D group. On the other hand, we found no statistically significant difference between the groups in the amount of blood lost during surgery detected by delta hemoglobin (p-value = 0.413).Conclusion: 3-D laparoscopy is very helpful and shortens surgical time, thereby reducing cost, exposure to anesthetic agents, and morbidity, thus improving the quality of care provided to the patient.