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343525

The Effect of Normalization of FSH/LH Ratio on the Response to Induction of Ovulation and Pregnancy Rate in Polycystic Ovary Syndrome Patients

Article

Last updated: 23 Dec 2024

Subjects

-

Tags

8. Male infertility and Sexual Health

Abstract

Objectives: To determine the role of normalization of FSH/LH ratio on the response to induction of ovulation and pregnancy 
rate in patients with polycystic ovarian disease.
Materials and Methods: This is a randomized controlled trial including 126 infertile women with PCOS attending to 
infertility clinic, Kasr Al-Ainy Maternity Hospital, Faculty of Medicine, Cairo University, from December 2021 until 
May 2022. Patients were divided into 2 equal groups:
- Group A (63 women): received OCPs for 3 successive cycles and after withdrawal bleeding of last cycle received 
clomiphene citrate 100 mg tablet orally started on 2nd day to 6th day of the cycle for five consecutive days for another 3 
cycles.
- Group B (63 women): didn't receive pre-treatment OCPs.
Results: The rate of normalization of FSH/LH ratio after COC pills was higher in group A 51/63 (81.0%). Ovulation 
rate, endometrial thickness at the day of HCG injection and clinical pregnancy rate after induction of ovulation were 
statistically significant higher in group A compared with group B. Also, total doses of gonadotropin used and percent of 
cases needed gonadotropin using for induction of ovulation were statistically significant lower in group A compared with 
group B.
Conclusion: In infertile PCOS patients, normalization of FSH/LH ratio in by using of a short pretreatment course of 
COCs could be used as it was proved to enhance ovulation rate, endometrial thickness at the day of HCG injection and 
clinical pregnancy rate. Also, it decreases need for using and total doses of gonadotropin and its side effects.

DOI

10.21608/ebwhj.2024.263463.1292

Keywords

Combined oral contraception, Ovulation Induction, PCOs, Pregnancy

Authors

First Name

Manal

Last Name

Moussa

MiddleName

-

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt

Email

manalmoussa@gmail.com

City

-

Orcid

-

First Name

Athar

Last Name

Shaaban

MiddleName

A.

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt.

Email

-

City

-

Orcid

-

First Name

Yahia

Last Name

Elfaissal

MiddleName

-

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Kamel

MiddleName

-

Affiliation

Department of Obstetrics & Gynecology, Faculty of Medicine, Cairo University, Egypt.

Email

ahmedkamel89@aun.edu.eg

City

-

Orcid

-

First Name

Bassiony

Last Name

Bassiony

MiddleName

Mohammed

Affiliation

Faculty of medicine, Cairo University

Email

bassiony.dabian@gmail.com

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

46341

Issue Date

2024-02-01

Receive Date

2024-01-16

Publish Date

2024-02-01

Page Start

105

Page End

109

Print ISSN

2090-7265

Online ISSN

2090-7257

Link

https://ebwhj.journals.ekb.eg/article_343525.html

Detail API

https://ebwhj.journals.ekb.eg/service?article_code=343525

Order

343,525

Type

Original Article

Type Code

366

Publication Type

Journal

Publication Title

Evidence Based Women's Health Journal

Publication Link

https://ebwhj.journals.ekb.eg/

MainTitle

The Effect of Normalization of FSH/LH Ratio on the Response to Induction of Ovulation and Pregnancy Rate in Polycystic Ovary Syndrome Patients

Details

Type

Article

Created At

23 Dec 2024