Background: The causes of female infertility are different and include genetic and anatomic abnormalities as well as endocrine and autoimmune disorders (ADs). Vitamin D might influence steroidogenesis of both estradiol and progesterone in healthy women where low levels of 25(OH)D levels might be associated with infertility.
Aim of the Work: To elucidate if there is relationship between vitamin D and unexplained infertility and if it more prevalent in them.
Patients and Methods: This case-control study was conducted at Ain Shams University Maternity Hospital during the period between October 2018-april 2019. A total of 70 women with prior history of unexplained infertility were included as group A (study group). A Second set of 70 fertile control group were included as group B (control group).
Results: Our study indicated that 25(OH) vitamin-D was significant lower in unexplained infertility group than control group (according to vitamin D level 39 out of 70 in unexplained infertility patient (55.7) had deficiency, while 30(42.9%) had insufficiency and 1(1.4) had sufficiency, in comparison to control group 21(30.0%) had deficiency, while 43(61.4) had insufficiency and 6(8.6%) had sufficiency), there were no significant correlation between 25(OH) vitamin D and age and BMI.
Conclusion: Vitamin-D deficiency had a role in unexplained infertility, nevertheless it is not a good diagnostic test. Unexplained infertility is multifactorial; Vit-D is only one of many factors/ theories.