Objectives: To find out the role of administration of indomethacin prior to embryo transfer in cases of difficult mock embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycle in improving the reproductive outcomes.
Study Design: It is a randomized controlled trial.
Patients and Methods: The study was conducted in the in vitro fertilization units of the University hospital as well as a private unit from the 2nd of June 2018 till the 2nd of December 2018. A total of two hundred in vitro fertilization/ intra cytoplasmic sperm injection cycles who had difficult mock embryo transfer on the day of ovum pick up. Women were randomly assigned into two groups; group A (study group: n=100) will receive 100mg indomethacin rectal suppository 1-2 hours before embryo transfer, while group B (control group: n=100) did not receive any medications before the embryo transfer.
Results: Both groups were comparable regarding age, body mass index, basal hormones, and cause of infertility. The implantation (23.7% vs 20.8%, P value 0.906), clinical pregnancy (48% vs 40%, P value 0.254), and ongoing pregnancy (40% vs 36%, P value 0.560) rates were higher in the indomethacin group, but not reaching statistical significance.
Conclusion: Indomethacin, as adjuvant therapy, has no statistically significant role on in cases with difficult embryo transfer in in-vitro fertilization/ intra cytoplasmic sperm injection cycles.