Abstract
Background The diagnostic performance, benefits, and drawbacks of optical coherence tomography angiography (OCTA) in comparison to existing imaging modalities are still unknown. Using OCTA, we conducted a meta-analysis research on vascular density (VD) in glaucoma patients.
Methods We personally examined the literature from January 2006 to March 2023 and also searched Web of Science, PubMed, Scopus, Google Scholar, ISI Conference Proceedings, and Prospective studies comparing the VD in open and closed angle glaucoma using OCTA.
Results The examination of meta-data contained 18 investigations out of 3045 evaluated publications. In 475 healthy eyes and 888 glaucomatous eyes, we found a statistically noteworthy decrease in the average peripheral visual defect (MPVD) in patients with glaucoma (57.53%, 95% CI 52.60 to 62.46, p<0.001). When contrasted to controls (65.47%, 95% Confidence Interval 59.82-71.11); standardized (95% CI –1.62 to –1.20, p<0.001), mean difference [SMD], –1.41). Likewise found that the mean-parafoveal VD (SMD, –3.92, 95% CI –4.73 to –3.12, p<0.001), mean inside-disc VD (SMD, − 9.51, 95% CI –12.66 to –6.36, p<0.05), and mean entire optic nerve image VD (SMD, –9.63, 95% CI –10.22 to –9.03, p<0.001). A considerable variation within the MPVD was seen between kinds of glaucoma and OCTA devices based on subgroup studies (open angle vs. closed angle glaucoma).
Conclusion OCTA is a reliable diagnostic tool for glaucomatous eyes, but further research is needed to understand the vascular changes linked to open and closed angle glaucoma.
Key words: Optical coherence Tomographic Imaging Angiography, Primary Open Angle Glaucoma, and Angle Closure Glaucoma