introduction: Vitiligo is a disfiguring condition that is asymptomatic. It is the most prevalent skin depigmentation condition brought on by a selective loss of epidermal melanocytes. A hormone called irisin has the ability to trigger vital alterations in adipose tissue, enhancing muscular function. Insulin resistance and metabolic syndrome improved with moderate elevations in irisin. Patients diagnosed with vitiligo have an increased chance of developing metabolic syndrome. Aim of work : assess the level of serum irisin level in vitiligo patients and to investigate its association with serum levels of both lipid profile and insulin as a marker of metabolic syndrome. Subjects and Methods: A cases control study was conducted on 60 participants; 30 of them were vitiligo patients and 30 were control. Complete history taking and dermatological examination were performed. Serum irisin, lipid profile and insulin levels investigated. Cases assessed by VASI, and VIDA scores. Results: Cholesterol and LDL level show a statistically significant higher level among vitiligo cases. A statistically positive correlation was found between Irisin level with both cholesterol and LDL level. In addition to a statistically significant positive correlation between insulin level (absorbance) and triglyceride level. According to the risk factors of vitiligo (age, sex, Irisin, insulin and lipid profile levels), there is no statistical significance. Conclusion: Vitiligo cases show higher level of cholesterol and LDL which positively associated with increase in irisin level that indicated risk of metabolic syndrome development among vitiligo cases.