Background: Numerous Th1/Th17-mediated inflammatory disorders have been linked to the immunological importance of interleukin 27 (IL-27). Numerous autoimmune and dermatological disorders have been associated with variations in IL-27 concentrations.
Aim of the work: to assess the correlation between serum levels of IL-27 and different types of skin diseases.
Subjects and methods: We searched PubMed, Web of Science, Cochrane, and SCOPUS for relevant articles. We utilized a strategy for our search by combining these keywords: ('' interleukin 27 '' OR '' IL-27 '' OR ''cytokine'') AND ('' psoriasis '' OR '' vitiligo '' OR '' multiple sclerosis '' OR '' keratoacanthoma '' OR '' squamous cell carcinoma ''). Quality assessment of the included studies was evaluated according to Cochrane's risk of bias tool.
Results: We found that the levels of serum IL-27 affected by different skin diseases as individuals suffering from psoriasis, systemic sclerosis, keratoacanthoma, basal cell carcinoma, and squamous cell carcinoma showed significantly higher levels of serum IL-27 than healthy controls. However, vitiligo patients showed significantly decreased levels of serum IL-27 than the control cohort
Conclusion: There is an association between the serum levels of IL-27 and several skin diseases such as vitiligo, psoriasis, systemic sclerosis, keratoacanthoma, basal cell carcinoma, and squamous cell carcinoma. Psoriasis, systemic sclerosis, keratoacanthoma, basal cell carcinoma, and squamous cell carcinoma were associated with high levels of serum IL-27.