Objectives: Tobacco consumption is mainly done in two forms, smoked tobacco and smokeless tobacco. This study was carried out to determine the negative effects of cigarette smoking, bidi smoking, and tobacco chewing on haematological parameters and to establish a link between them. Material and methods: A matched comparative cross-sectional study was carried out in the Upgraded Department of Physiology in partnership with the Department of Medicine at SMS Medical College, Jaipur. The study included 210 apparently healthy people (70 cigarette smokers, 70 bidi smokers, 70 tobacco chewers, and 70 non-tobacco users). Blood samples (venous) were collected for the estimation of haematological parameter. Results: Non-Significant changes were observed in the complete blood profile in cigarette smoking, bidi smoking and tobacco chewers when compared to nonusers except TWBC and RDW-CV. Hb, Monocyte, Eosinophil Counts, Platelet Counts, PCT and MPV were higher in tobacco users than the control group. The lymphocyte and basophil count were found to be lower in tobacco users compared to the control group. The mean and standard deviation of HCT increased in bidi and cigarette smokers but decreased in tobacco chewers compared to the control group. RDW-CV and TWBC significantly increases in the tobacco users groups than the control group. Conclusion: The current study may be beneficial in raising knowledge on the adverse effect on the population using tobacco.