Background: Cases who suffer from psoriasis exhibit an elevated type I interferon signature. Interferon-kappa, often known as Interferon -κ, is a group of interferons belonging to the type I interferon family. Keratinocytes are predominantly responsible for its expression. For the purpose of this investigation, we are examining whether IFN-κ has a role in the etiology of psoriasis.
Aim of work: This investigation was conducted to determine whether Interferon -κ, a type I interferon that is constitutively generated by keratinocytes, was implicated in the etiology of psoriasis.
Subjects and Methods: There were twenty cases who had psoriatic arthritis & twenty healthy participants who served as the control group. A comprehensive clinical examination was carried out, & measurements were taken of the levels of IFN-k in both the tissue & the serum.
Results: In our study we observed that there was significant elevation in human interferon kappa levels in serum and tissue for psoriasis patients compared to control group, we also found that there were no significant correlations detected between human interferon kappa levels in serum and tissue for psoriasis patients & the degree of severity of the illness
Conclusion: Taking into consideration the results of our investigation, it can be speculated that INF-k can contribute to the etiology of the psoriasis.