Background: Damage to different organs is caused by aberrant responses from the innate and adaptive immune systems in autoimmune disorders, which encompass a variety of issues. The cause of autoimmune diseases is a very complex and poorly understood phenomenon. Patients and methods: Our search result contained original research from PubMed, Medline, and EMBASE. There were no review papers included. Studies must have published at least one lncRNA that they discovered through experimentation. Results: Psoriasis, alopecia areata, systemic sclerosis, and melanoma were among the autoimmune dermatological conditions that were mentioned. With the exception of alopecia areata, where expression was downregulated relative to control, HOTAIR expression was significantly higher in cases of autoimmune dermatological diseases than in the control group in all cases. Conclusion: We can conclude that the long non-coding RNA known as HOTAIR functions as a diagnostic marker for skin autoimmune diseases and it also might play a role in their pathogenesis.