Abstract
Background: Verrucae vulgaris is a dome-shaped hyperkeratotic papule that is brought on by HPV, which damages immune response cells known as epithelial cells, which are the first line of defense against infection. CD40, a member of the tumor necrosis factor receptor class, is expressed on keratinocytes among other types of cells. The immune response against HPV infection is elicited by the ligation of CD40 with its ligand, CD40L.
Objectives: this study aims to evaluate the level of CD40 expression in tissue of verruca vulgaris infection and its correlation to local characteristics.
Patients & Methods: tissue level of CD40 were evaluated in verruca vulgaris patients in comparison to normal subjects.
Results: after the search and screening one study was eligible for inclusion in our meta-analysis.
Results of meta-analysis showed that CD40 were higher patients than controls. The pooled effect estimate that tissue levels showed only significance in relation to disease onset. HPV detection was associated with CD40 expression (r = 0.570, P < 0.05).
Conclusion: Our study may provide evidence of rising of CD40 levels in verruca vulgaris patients which plays important in role immune response elicited against HPVs causing verruca vulgaris.
Key wards: HPV, verruca vulgaris, CD40, warts.