One of most prevalent endocrine disorders is thyroid dysfunctions. Which has a significant impact on mortality and morbidity, which has a significant global health care impact. Thyroid hormone has a significant impact on every cell in the body.
The connection among thyroid problems and blood coagulation systems was first mentioned scientifically at the beginning of the previous century. In patients with thyroid dysfunction, numerous acquired coagulation-fibrinolytic system abnormalities were studied.
This study's objective is to evaluate novel biomarkers as thrombosis predictors in thyroid dysfunction patients.
Patients and methods:
This case-control study included the following participants:
Twenty patients in Group A, who have hyperthyroidism, have elevated thyroid functions.
Group B contains 20 patients with hypothyroidism who have decreased thyroid function.
Group C consists of 20 individuals with normal thyroid function (the euthyroid group).
after taking a complete medical history (including OCPS use), age, gender, smoking, history of cancer, thromboembolic events & bleeding disorders. A thorough clinical examination was also done. For lab tests and measurements of the CBC, PT, PTT, PC, TSH, FT4, D. DIMER, and P. SELECTIN LEVEL, blood samples were taken.
Results: The study groups did not differ significantly from one another regarding the PT-INR, PTT, and D-dimer levels also the CBC components.
Additionally, PTT and PLT count levels were a significant predictor of p-selectin level.
Conclusion, it can be concluded that there was no significant variance among study groups Concerning CBC components, PT-INR, PTT and D-dimer level.