ABSTRACT:
Background: 18F-FDG PET/CT is used for management evaluation of lymphoma with different parameters for PET and CT. However, there is no definite parameter to be used as golden standard. Aim of the Work: Evaluation of role of 18F-FDG PET/CT in assessment of lymphoma management with comparison of different parameters. Patients and Methods: One-hundred patients with different lymphoma histopathology attended to clinical oncology and nuclear medicine department - Kasr Al-Ainy hospital (NEMROCK), had been retrospectively studied looking for different parameters like PET and CT parameters for evaluation of the lesions together with assessment of treatment response. Results: This study included 36 patients with Hodgkin disease (HD) and 64 with Non-Hodgkin lymphoma (NHL). Comparison between initial mean values of SUVmax with ±S.D in Hodgkin and non-Hodgkin lymphoma shows no significant difference (p>0.05). Responders were found to be 86% and 14% were non-responders with very high degree of matching between qualitative and quantitative PET parameters and poor matching between them and CT assessment for response. Regression analysis revealed that the most determinant factors for survival were Lugano and Deuville (30% impact for each) together SUVmax and delta SUVmax (33% for both together). Conclusion: 18F-FDG PET/CT is an important tool for assessing response and survival in lymphoma.