Objective: Assess correlation between the 18F FDG PET/CT volumetric parameters and clinico-pathological prognostic factors in metastatic breast cancer Methods: In this prospective study we included 52 patients who underwent F18 FDG PET/CT with metastases to loco/regional lymph nodes, distant metastases were detected in 22 of them. The association of maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume (MTV), tumour/liver uptake ratio (TLR) and total lesion glycolysis (TLG) of the loco/regional lymph nodes and distant metastases with clinico-pathological prognostic factors were assessed. Results: There were significant correlations between regional lymph nodes metastases SUVmax and SUVmean and tumor grade & N stage , while no significant correlation was found regarding the other parameters including focality of the primary tumor , histology , ER , PR , HER2 , KI67 , molecular subtype and M stage. On the other hand regional lymph nodes metastases MTV, TLG and TLR, correlation was found regarding N stage only and no significant correlation was found regarding the other parameters. No significant correlations between volumetric parameters of bone metastases and clinic-pathological risk factors could be elicited. Conclusion: Volumetric parameters of the metastatic loco-regional lymph nodes in breast cancer can reflect aggressiveness of the tumor, therefore can help in therapy planes, while this not found regarding bone metastases.